Research project
Multi-Contrast Quantification of Perfusion Using Joint Magnetic Resonance Contrast-Enhanced and Arterial-Spin-Labeling Approaches
Abstract.
Magnetic resonance (MR) perfusion imaging is used for diagnostics and therapy monitoring
mostly in oncology, neurology and cardiology, providing assessment of the perfusion status of a
tissue on the capillary level. However, current MR perfusion imaging methods are still not ready
for routine clinical use. They still remain mostly on the experimental level. The main methods for
MR perfusion imaging are Dynamic Contrast-Enhanced (DCE) MRI, Dynamic Susceptibility-Contrast (DSC) MRI and Arterial Spin Labeling (ASL).
So far, they have been treated as
competing and were compared among each other to find the best one.
In this project, we propose a very different approach that might push MR perfusion imaging
towards a reliable reproducible measurement method. We propose a connection of these MR
perfusion imaging approaches using a joint approach. We will develop advanced interconnected
pharmacokinetic models, compressed-sensing MR acquisition and image reconstruction
schemes that utilize the complementary information provided by these three methods.
Goals.
1/ Formulate interconnected pharmacokinetic models of DCE, DSC and ASL for joint perfusion
analysis. 2/ Design joint DCE-DSC-ASL acquisition and processing algorithms.
3/ Overcome the limits of low temporal resolution and low signal-to-noise ratio by new
compressed-sensing methods.
Keywords: magnetic resonance; perfusion; pharmacokinetic modeling; optimization; regularization; compressed sensing; DCE; DSC; ASL
Duration:
2022–2024
The consortium:
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Signal Processing Laboratory, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno
prof. Mgr. Pavel Rajmic, Ph.D.
Ing. Marie Mangová, Ph.D.
Ing. Ondřej Mokrý
Funding